Blood Samples from Subject 6 months through 7 years of age for Reference Interval Determinations for Clinical Laboratory Tests

• Parental Permission Form

Clinical laboratory testing is generally done by measurement of substances in serum or urine. In order to validate a method for use in the diagnosis of clinical disorders, the hormones or chemical substances must be measured in large normal populations of various ages and both genders. Once the reference intervals for normal subjects are determined, the test can then be used more accurately for the diagnosis of clinical disorders. The purpose of this protocol is to collect both blood and urine specimens from normal subjects for the purpose of determining pediatric reference intervals for a number of clinical laboratory assays.

Length of Study: Indefinite (2-3 years will probably be required)

Number of Subjects: 1,680 for entire study

Characteristics of Participants: Boys and girls between the ages of 6 months and 7 years who are willing and able to provide a blood sample.

Subject Groups Excluded: Those with any chronic medical condition requiring prescription medications(s).

Location of Study: Primary Children's Medical Center, Salt Lake City, Utah

Analytes:

Serum (31):
Albumin
Aldolase
Amylase
Androstenedione
Calcium
Ceruloplasmin
C-reactive protein
Creatine kinase
Dehydroepiandrosterone sulfate (DHEAS)
11-Deoxycortisol
Estradiol
Estrone
Growth hormone
17-Hydroxypregenolone
17-Hydroxyprogesterone
IgA
IgE
IgG
IgG subclasses
IgM
Insulin-like growth factor I
Insulin-like growth factor binding protein-3
N-telopeptide
Osteocalcin
Parathyroid hormone
Prealbumin
Pregnenolone
Prolactin
Sex hormone binding globulin (SHBG)
Testosterone
Uric acid