Blood and Urine Samples for Pediatric Reference Interval Determinations for Clinical Laboratory Tests
Clinical laboratory testing is generally done by measurement of substances in serum or urine. In order to validate a method for use in the diagnosis of clinical disorders, the hormones or chemical substances must be measured in large normal populations of various ages and both genders. Once the reference intervals for normal subjects are determined, the test can then be used more accurately for the diagnosis of clinical disorders. The purpose of this protocol is to collect both blood and urine specimens from normal subjects for the purpose of determining pediatric reference intervals for a number of clinical laboratory assays.
Length of Study: Indefinite (2–3 years will probably be required)
Number of Subjects: 2,640 for entire study
Characteristics of Participants: Healthy males and females between the ages of 7 and 17 years who are willing and able to provide both a blood and urine sample
Subject Groups Excluded: Those with any chronic medical condition
Location of Study: ARUP Laboratories, Salt Lake City, Utah
Analytes:
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Serum (88):
Albumin
Aldolase
Alkaline phosphatase
Alpha-1-antitrypsin
Alpha-fetoprotein
ALT
Amylase
Pancreatic amylase
Androstenedione
Angiotensin converting enzyme
Anti-citrullinated cyclic peptide antibodies
Anti-chitobioside carbohydrate antibodies
Anti-DNase B antibodies
Anti-mannobioside carbohydrate antibodies
Anti-streptolysin O antibodies
Anti-thyroglobulin antibodies
Anti-thyroid peroxidase antibodies
AST
Beta-2-microglobulin
Bile acids
Bone specific alkaline phosphatase
BUN
Calcium
Cartilage oligomeric matrix protein
Ceruloplasmin
Cobalt
Complement component 2
Complement component 3
Complement component 4
Complement component 5
Total complement activity
Copper
Cortisol
11-deoxycortisol
11-deoxycorticosterone
Creatine
Creatine kinase
Creatinine
CTX
Dehydroepiandrosterone sulfate
Dehydroepiandrosterone
Erythropoietin
Essential fatty acids
Estradiol
Estriol
Estrone
FSH
GGT
Growth hormone
Guanidinoacetate
17-Hydroxyprogesterone
25-Hydroxyvitamin D
Immunoglobulin A
Immunoglobulin E
Immunoglobulin G
Immunoglobulin G subclasses
Immunoglobulin M
Insulin-like growth factor-1
IGF binding protein-3
LD
LH
Lipase
Manganese
N-telopeptide crosslinks
Nickel
Osteocalcin
P1NP
Parathyroid hormone
Phosphorous
Prealbumin
Pregnenolone
17-hydroxypregnenolone
17-hydroxyprogesterone
Progesterone
Prolactin
Rheumatoid factor
Sex hormone binding globulin
T3
FT3
T4
FT4
Testosterone
Transferrin
TSH
Uric acid
Vitamin A
Vitamin E
Zinc
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Plasma (20):
Alpha-2-antiplasmin
Antithrombin
D-dimer
Factor II
Factor V
Factor VII
Factor VIII
Factor IX
Factor X
Factor XI
Fibrinogen
Partial thromboplastin time
Plasminogen
Protein C functional
Protein C antigen
Protein S function
Protein S antigen
Prothrombin time
von Willebrand factor antigen
von Willebrand factor (ristocetin cofactor)
Urine (12):
Calcium
Catecholamines (epinephrine, norepinephrine, dopamine)
Free cortisol
Creatinine
Homovanillic acid
Metanephrines (metanephrine, normetanephrine)
Microalbumin
N-telopeptide cross-links
Oxalate
Phosphorus
Total Protein
Vanillylmandelic acid
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